WebDec 1, 2016 · Higuchi (1961 & 1963) developed number of mathematical theoretical models to study the release of drugs (water soluble and poorly water soluble) from various matrix systems ( Siepmann and Peppas, 2011 ). WebOct 28, 2000 · To describe the kinetics of drug release from the test formulation, zero-order, first-order, Higuchi's, Hixson-Crowell's, and Weibull's models were used. The criterion for selecting the most appropriate model was based on the goodness-of-fit test. The release kinetics of the tablets and microspheres were explained by the Higuchi model.
Investigation of Kinetic Drug Release Characteristics and In Vitro ...
WebJun 8, 2024 · This could explain why the drug diffuses at a reasonably slower rate as the distance for diffusion increases, which is referred to as square-root kinetics or Higuchi kinetics. The R 2 value of the drug was calculated using the Higuchi model [ 15 ]; it was calculated from the plot of percentage cumulative drug release against the square root of ... WebMar 14, 2024 · Peppas-Shalin equation was the majority descriptor of release suggesting a combination of Fickian and erosion processes, revealing a decrease in the Fickian component as drug loading increased. Major burst release risks were evidenced mostly with Higuchi kinetics with vinylacetate acrylates. bishop tyrone butler
Formulation and Evaluation of Floating Tablet of Metformin ...
WebNov 28, 2024 · Higuchi model A graph of %CDR against SQRT was plotted to study the release kinetics. Korsmeyer–Peppas model A graph log %CDR against log time was plotted to study the release kinetics. Hixson–Crowell model A graph of CBRT %DR against time was plotted to study the release kinetics [ 14 ]. 2.3.7 Scanning electron microscopy WebOct 1, 2001 · Kinetics of the base-catalyzed self-condensation of 4-hydroxymethylphenol (4-HMP) was investigated for the purpose of clarifying the mechanisms of the phenolic resin curing. ... M. Higuchi, Y ... WebApr 14, 2024 · The data suggest that the release from the hydrogel samples studied was best described by Higuchi’s model. In order to further clarify the release kinetics, Figure 9a–c shows the Higuchi’s model curves for all samples. These finding suggests that the developed hydrogel matrices are effective in controlling release via a diffusion mechanism. bishop tyrrell anglican college fletcher