Cisplatin pulmonary fibrosis

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August undefined, 2024

WebAbstract. Idiopathic pulmonary fibrosis (IPF) is a deadly and progressive fibrotic lung disease, but the precise etiology remains elusive. IPF is characterized by the presence … WebAbstract. Combination chemotherapy that included bleomycin and cisplatin was administered to 45 evaluable patients (30 with cervix carcinoma and 15 with germ cell …

Dissecting the Crosstalk Between Nrf2 and NF-κB Response …

WebApr 15, 2024 · Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with unclear pathogenesis. IPF is considered as a risk factor for lung cancer. … WebJan 1, 2011 · Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis. Cancer Res 2003;63(16):5054–5059. Medline, Google Scholar; 24 Wagner SA, … how to stream ink master

Pirfenidone as salvage treatment for refractory bleomycin …

WebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary … WebFeb 22, 2016 · In patients treated for disseminated testicular cancer with bleomycin, etoposide, and cisplatin (BEP), the risk of acute bleomycin-induced changes is ≤ 6.8%, with a 0% to 1% risk of death. 1 - 4 Serious long-term toxicity has been indicated with an increased risk of late mortality caused by pulmonary diseases. 5 These findings were … WebMar 2, 2016 · Cisplatin is known to intercalate DNA by the formation of cross-links. The damage done by cisplatin leads to inhibition of DNA replication followed by apoptosis or … reading 98 lineup

Increased pulmonary toxicity with bleomycin and cisplatin …

Cisplatin Side Effects: Common, Severe, Long Term

WebMar 8, 2024 · Cisplatin is implicated in promoting lung fibrosis, which indicates that IPF fibroblasts cultured on a collagen matrix are resistant to cisplatin-induced cell death. To test this, we first treated non-IPF and IPF fibroblasts (n = 8 each) with various doses of cisplatin, and their viability was measured. WebAug 7, 2024 · Its potent anti-inflammatory and anti-fibrotic effects were demonstrated in animal models of lung fibrosis including bleomycin-induced lung injury and fibrosis. Oku et al. showed that both prophylactic and therapeutic administration of pirfenidone attenuated lung fibrosis induced by intravenous bleomycin in mice [ 5 ]. how to stream inside manWebAlthough cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity 掌桥科研一站式科研服务平台 reading 97 line up

"WebCisplatin and Pulmonary fibrosis, a phase IV clinical study of FDA data - eHealthMe. Pulmonary fibrosis is found among people who take Cisplatin, especially for people who … " - Cisplatin pulmonary fibrosis

Cisplatin pulmonary fibrosis

The anti-fibrotic agent pirfenidone synergizes with cisplatin in ...

WebFeb 24, 2024 · Certain chemotherapy medications, such as cisplatin, can cause damage to the kidneys and bladder. This can result in a decreased ability of your kidneys to filter your blood. Damage to the bladder can also occur and may be temporary or permanent. Symptoms of bladder irritation may include pain or urgency with urination, or blood in … WebJan 23, 2024 · Interstitial lung disease is the most common syndrome; it may progress to end-stage pulmonary fibrosis. The clinical presentation is typically subacute, with …

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Commonly reported side effectsof cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of adverse effects. Applies to cisplatin: intravenous powder for solution, intravenous solution. See more Along with its needed effects, cisplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do … See more Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some side effects may not be reported. You … See more Some side effects of cisplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your … See more WebBackground: Gemcitabine is the only approved cytotoxic agent for the treatment of pancreatic cancer by the Food and Drug Administration. In addition, gemcitabine is also commonly used for the management of breast, ovarian, and non-small cell lung cancer. Myelosuppression is the most common toxicity of gemcitabine therapy.

WebThe clinical and histopathological data as well as the lack of an infectious cause indicate that pulmonary fibrosis was induced by oxaliplatin and 5-FU/folinic acid. Conclusion: This case demonstrates that treatment with oxaliplatin and 5-FU/folinic acid can cause acute pulmonary fibrosis. WebPubMed Central (PMC)

WebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, WebSep 8, 2024 · Interstitial lung disease (ILD) is a disease with progressive deterioration of respiratory function ( 1 ). ILD is an independent risk factor for lung cancer (LC). Among patients diagnosed with lung cancer, 5.8–15.2% of patients have ILD ( 2, 3 ).

WebThe fibrosis consisted of mildly inflamed, densely scarred tissue with thin dilated vessels, and was present to a significant extent that is suggestive of spontaneous regression. ... etoposide and cisplatin), which were completed in 80 days. There was no evidence of disease in 3.4 years of post-operative follow-up with serum and imaging studies ...

WebThe anticancer drug cisplatin induces cell death by apoptosis. Apoptosis is dependent on cellular loss of potassium ions (K+). We have recently shown that the antifungal drug amphotericin B (enhancin how to stream internet radioWebNov 26, 2024 · Ginkgolic C17:1 or cisplatin alone inhibited the PI3K/AKT/mTOR pathway in hepatoblastoma HepG2 cells, and co-treatment exhibited an enhanced inhibitory effect, while in normal hepatocytes, ginkgolic C17:1 alone did not significantly impact this signaling pathway, rather reducing cisplatin-caused inhibition to prevent cell damage [ 43 ]. reading 98/99WebPulmonary toxicity of cytotoxic agents Platinum compounds The administration of cisplatin and carboplatin, the 2 most commonly used platinum derivative agents, can lead to … how to stream ipad to obsWebPulmonary toxicity is one of the most serious adverse effects associated with a quick course of vincristine, bleomycin, and cisplatin neoadjuvant chemotherapy (NAC-VBP). The aim of this study was to evaluate pulmonary toxicity related to a quick course NAC-VBP. how to stream internet to tv wirelesslyWebOct 15, 2024 · Cisplatin forms intrastrand crosslinks in DNA, which disturbs DNA replication and causes DNA damage, eventually inducing necrosis or apoptosis. Cisplatin-based chemotherapy is widely used to... reading 99 coal water heatersWebApr 10, 2024 · In addition, pulmonary toxicity is a common but significant side effect of bleomycin which can lead to pulmonary fibrosis and increased mortality (Brandt and Gerriets, 2024). ... paclitaxel in combination with cisplatin has been used to treat ovarian mucinous adenocarcinoma during pregnancy with no negative outcomes to the child, ... how to stream internet tv on apple carplayWebThe administration of aerosol bronchodilators and corticosteroids are used by several patients with respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis, bronchiectasis, and lung infection [32,33,34]. Bronchodilators are known to dilate the airways that are narrowed due to the underlying ... reading 99 line up