WebChromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release. WebChromofungin is an antimicrobial peptide with antifungal activity. Catestatin is an antimicrobial peptide with activity against bacteria, fungi, and malaria. CgA and CgB have been used as general NEN biomarkers for many years, while CART has only recently been identified High serum CHGA levels are associated with small-cell lung cancer.
CHGA Gene - GeneCards CMGA Protein CMGA Antibody
WebNew endogenous antimicrobial peptides (AMPs) derived from chromogranin A (CgA) are secreted by nervous, endocrine and immune cells during stress. They display antimicrobial activities by lytic effects at micromolar range using a pore-forming mechanism against Gram-positive bacteria, filamentous fungi and yeasts. WebOct 31, 2024 · Eissa N, Hussein H, Kermarrec L, et al. Chromofungin (CHR: CHGA47-66) is downregulated in persons with active ulcerative colitis and suppresses pro-inflammatory macrophage function through the inhibition of NF-kappaB signaling. Biochem Pharmacol. flowers ithaca
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WebJan 19, 2024 · Chromogranin is categorized into three subgroups: the most abundant type was recognized as chromogranin A (CgA) [ 12] in 1968; the two remaining types of less … WebChromofungin (CHR: chromogranin-A 47-66) is a chromogranin-A derived peptide with anti-inflammatory and anti-microbial properties. Ulcerative colitis (UC) is characterized by a colonic decrease of CHR and a dysregulation of dendritic CD11c + cells. The most active shortest peptide, named chromofungin, corresponds to the sequence Arg47–Leu66. Extensive1H NMR analysis revealed that it adopts a helical structure. The biophysical mechanism implicated in the interaction of chromofungin with fungi and yeast cells was studied, showing the penetration of this peptide with different lipid ... green bean \u0026 potato casserole